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Synthesis by Escherichia coli of an abnormal β-galactosidase in the presence of thiouracil

par Hamers, Raymond ;Casterman, Cécile
Référence Journal of Molecular Biology, 3, 2, page (166-174)
Publication Publié, 1961

Article révisé par les pairs

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Résumé :

In the presence of 2-thiouracil, the increase in β-galactosidase activity is inhibited to a greater extent than the corresponding protein assayed immunologically. It seems that the protein synthesized in the presence of the analogue loses some of its enzymic sites. It is suggested that this is a consequence of thiouracil incorporation into RNA templates or eventually into S-RNA. © 1961, Academic Press Inc. (London) Ltd.. All rights reserved.