METHOD FOR DETERMINING SENSITIVITY TO A CDK4/6 INHIBITOR

Raspé, Eric; Roger, Pierre P.; Coulonval, Katia; Paternot, Sabine; Pita, Jaime Miguel; Sotiriou, Christos; Ignatiadis, Michail; Rothé, Françoise

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METHOD FOR DETERMINING SENSITIVITY TO A CDK4/6 INHIBITOR

par Raspé, Eric

Publication Publié, 2019-11-14

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Résumé :

The present invention relates to a method for determining sensitivity to a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor in a human subject having breast cancer, the method comprising determining in a sample from the subject the level of expression of 11 genes as defined in the claims. The present invention further provides kits of parts, nucleic acid arrays, and uses thereof for determining sensitivity to a CDK4/6 inhibitor in a human subject having breast cancer. The present invention also relates to methods of treating a human subject having breast cancer, comprising administering a therapeutically effective amount of the CDK4/6 inhibitor to the subject.

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METHOD FOR DETERMINING SENSITIVITY TO A CDK4/6 INHIBITOR
par Raspé, Eric , Roger, Pierre P. , Coulonval, Katia , Paternot, Sabine , Pita, Jaime Miguel , Sotiriou, Christos , Ignatiadis, Michail , Rothé, Françoise
Publication 2021-04-14
Monoclonal antibodies to activated CDK4: use to investigate normal and cancerous cell cycle regulation and involvement of phosphorylations of p21 and p27.
par Coulonval, Katia , Vercruysse, Vincent , Paternot, Sabine , Pita, Jaime Miguel , Corman, Robert , Raspé, Eric , Roger, Pierre P.
Publication 2022-01-21
CDK4/6 Inhibitors in Pancreatobiliary Cancers: Opportunities and Challenges
par Arsenijevic, Tatjana , Coulonval, Katia , Raspé, Eric , Demols, Anne , Roger, Pierre P. , Van Laethem, Jean-Luc
Publication 2023-02-01
CDK4 phosphorylation status and rational use for combining CDK4/6 and BRAF/MEK inhibition in advanced thyroid carcinomas.
par Pita, Jaime Miguel , Raspé, Eric , Coulonval, Katia , Decaussin-Petrucci, Myriam , Tarabichi, Maxime , Dom, Geneviève , Libert, Frédérick , Ruscas-Craciun, Ligia Ioana , Andry, Guy , Wicquart, Laurence , Leteurtre, Emmanuelle , Tresallet, Christophe , Marlow, Laura A , Copland, John A , Durante, Cosimo , Maenhaut, Carine , Cavaco, Branca Maria , Dumont, Jacques Emile , Costante, Giuseppe , Roger, Pierre P.
Publication 2023-10-26
CDK4 phosphorylation status and rational use of CDK4/6 inhibitors in advanced thyroid cancers
par Pita, Jaime Miguel , Coulonval, Katia , Costante, Giuseppe , Myriam, Decaussin , Emmanuelle, Leteurtre , Cavaco, Branca Maria , A, Copland John , Durante, Cosimo , Maenhaut, Carine , Dumont, Jacques , Roger, Pierre P. , Raspé, Eric
Publication 2022-09-01

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