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Two sites of airway obstruction identified by post-bronchodilation change of exhaled nitric oxide in COPD patients

par Perez Bogerd, Silvia ;Michils, Alain ;Malinovschi, Andrei;Van Muylem, Alain
Référence The European respiratory journal, 48, S60, PA1848
Publication Publié, 2016

Article révisé par les pairs

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Résumé :

Background: We have shown that the change of exhaled nitric oxide (FENO) after bronchodilation allows to identify the site of airway obstruction in asthma: FENO stability, increase, or decrease reflects obstruction relief by bronchodilation up to central, pre-acinar and intra-acinar airways (1).Aim: To investigate whether FENO change after bronchodilation is able to identify different sites of airway obstruction in COPD patients.Methods: FENO, FEV1, and the slope (S) of phase III of He, and SF6 from a single-breath test were measured in 41 stable COPD patients with median(range) FEV1 of 48(20-78)%predicted before and 20 minutes after inhalation of 400 µg salbutamol. SHe and SSF6 decrease reflects pre- and intra-acinar obstruction relief respectively. Changes (Δ) were expressed as a percentage of baseline.Results: No FENO change (