par Gerard, Phideline 
;Evano, Gwilherm
Référence Letters in Organic Chemistry, 15, page (359-364)
Publication Publié, 2018
;Evano, Gwilherm Référence Letters in Organic Chemistry, 15, page (359-364)
Publication Publié, 2018
Article révisé par les pairs
| Résumé : | An efficient procedure for the direct arylation of pyrrolidine with phenols and naphtols is reported. Upon reaction with catalytic amounts of a binuclear copper(II)-7-azaindole complex under an atmosphere of oxygen, pyrrolidine is smoothly oxidized to the corresponding imine which can be trapped in situ by a series of phenols and naphtols in fair to good yields. This copper-catalyzed direct oxidative arylation of pyrrolidine offers an efficient entry to alpha-aryl-pyrrolidines in a single step and without the need for protecting or directing groups. |
