Titre:
  • The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity.
Auteur:Wali, Jibran JA; Rondas, Dieter; McKenzie, M D; Zhao, Y; Elkerbout, L; Fynch, S; Gurzov, Esteban Nicolas; Akira, S; Mathieu, Chantal; Kay, T W H TW; Overbergh, Lut; Strasser, Andreas; Thomas, Helen H.E.
Informations sur la publication:Cell death & disease, 5, page (e1124)
Statut de publication:Publié, 2014-03
Sujet CREF:Sciences bio-médicales et agricoles
MeSH keywords:Animals
Antioxidants -- pharmacology
Apoptosis -- drug effects
Apoptosis Regulatory Proteins -- deficiency -- genetics -- metabolism
Bcl-2-Like Protein 11
Cell Line
Diabetes Mellitus, Type 2 -- metabolism -- pathology
Endoplasmic Reticulum -- drug effects -- metabolism -- pathology
Endoplasmic Reticulum Stress -- drug effects
Glucose -- metabolism
Humans
Insulin-Secreting Cells -- metabolism -- pathology
Islets of Langerhans -- drug effects -- metabolism -- pathology
Membrane Proteins -- deficiency -- genetics -- metabolism
Mice
Mice, 129 Strain
Mice, Inbred C57BL
Mice, Knockout
Mitochondria -- drug effects -- metabolism -- pathology
Oxidants -- pharmacology
Oxidative Stress -- drug effects
Proto-Oncogene Proteins -- deficiency -- genetics -- metabolism
RNA, Messenger -- metabolism
Ribose -- metabolism
Tissue Culture Techniques
Transcription Factor CHOP -- deficiency -- genetics
Tumor Suppressor Proteins -- deficiency -- genetics -- metabolism
Langue:Anglais
Identificateurs:urn:issn:E230326
info:doi/10.1038/cddis.2014.88
info:pii/cddis201488
info:pmid/24625983
PMC3973197