Article révisé par les pairs
Titre:
  • KLF4 is a key determinant in the development and progression of cerebral cavernous malformations.
Auteur:Cuttano, Roberto; Rudini, Noemi; Bravi, Luca; Corada, Monica; Giampietro, Costanza; Papa, Eleanna; Morini, Marco Francesco; Maddaluno, Luigi; Baeyens, Nicolas; Adams, Ralf H; Jain, Mukesh MK; Owens, Gary GK; Schwartz, Martin Alexander; Lampugnani, Maria Grazia; Dejana, Elisabetta
Informations sur la publication:EMBO molecular medicine, 8, 1, page (6-24)
Statut de publication:Publié, 2016-01
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:CCM
EndMT
KLF4
TGFβ‐BMP
endothelial cells
MeSH keywords:Animals
Bone Morphogenetic Protein 6 -- antagonists & inhibitors -- genetics -- metabolism
Cell Proliferation
Disease Models, Animal
Disease Progression
Endothelial Cells -- cytology -- metabolism
HEK293 Cells
Hemangioma, Cavernous, Central Nervous System -- genetics -- metabolism -- pathology
Humans
Kruppel-Like Transcription Factors -- antagonists & inhibitors -- genetics -- metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Microtubule-Associated Proteins -- antagonists & inhibitors -- genetics -- metabolism
Mitogen-Activated Protein Kinase 7 -- metabolism
Mutation
Proto-Oncogene Proteins -- antagonists & inhibitors -- genetics -- metabolism
RNA Interference
Signal Transduction
Smad1 Protein -- metabolism
Transforming Growth Factor beta -- metabolism
Langue:Anglais
Identificateurs:urn:issn:1757-4676
info:doi/10.15252/emmm.201505433
info:pii/emmm.201505433
info:pmid/26612856
PMC4718159

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