par Bleiberg, Harry 
;Mainguet, Paul ;Galand, Paul ;Chretien, J.;Mairesse, Nicole
Référence Gastroenterology, 58, 6, page (851-855)
Publication Publié, 1970
;Mainguet, Paul ;Galand, Paul ;Chretien, J.;Mairesse, Nicole Référence Gastroenterology, 58, 6, page (851-855)
Publication Publié, 1970
Article révisé par les pairs
| Résumé : | The generation time of the regenerative population in the human rectal mucosa was studied in normal subjects and in patients with ulcerative colitis. The double labeling technique with two pulses of 3H-thymidine, followed by autoradiography, was applied to biopsies incubated in vitro. The results showed that the mean turnover time in ulcerative colitis was significatively shorter than in the normal tissue (34 and 90 hr, respectively; 0.01 > P > 0.001). An extension of the regenerative zone toward the upper part of the crypts was also observed. This suggests that in ulcerative colitis the morphological evolution of the rectal mucosa toward atrophy, which expresses an alteration of the normal equilibrium between cell loss and cell production, is explained by an increased rate of cell desstruction rather than by decreased rate of cell formation. © 1970, The Williams & Wilkins Co.. All rights reserved. |
