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Investigations into the antitumour activity of organotin compounds. I. Diorganotin dihalide and di-pseudohalide complexes

par Crowe, Alan J.Alan;Smith, Peter;Atassi, Ghanem
Référence Chemico-biological interactions, 32, 1-2, page (171-178)
Publication Publié, 1980

Article révisé par les pairs

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Résumé :

The antitumor activity of a series of diorganotin dihalide and di-pseudohalide complexes, R2SnX2, L2, where R = Methyl (Me), Ethyl (Et), n-Propyl (Pr), n-Butyl (Bu) or Phenyl (Ph); X = F, Cl, Br, I or NCS; and L = O- or N- donor organic ligand, which were modelled on the active platinum complexes, has been investigated. A number of these derivatives exhibit reproducible therapeutic activity in vivo towards P-388 lymphocytic leukaemia in mice, particularly the diethyltin dihalide and dipseudohalide complexes. The possible factors influencing activity are discussed, both in terms of the stereo-chemistry of the dialkyltin compounds and their structural similarity to the platinum antitumour drugs. © 1980, All rights reserved.