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Physicochemical characterizations of functional hybrid liposomal nanocarriers formed using photo-sensitive lipids

par Pramanik, SK;Losada Perez, Patricia ;Reekmans, Gunter;Carleer, Robert;D'Olieslaeger, Marc;Vanderzande, Dirk J M D.;Adriaensens, Peter J A P.;Ethirajan, Anitha
Référence Scientific Reports, 7, page (46257)
Publication Publié, 2017-04-13

Article révisé par les pairs

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Résumé :

With recent advances in the field of diagnostics and theranostics, liposomal technology has secured a fortified position as a potential nanocarrier. Specifically, radiation/photo-sensitive liposomes containing photo-polymerizable cross-linking lipids are intriguing as they can impart the vesicles with highly interesting properties such as response to stimulus and improved shell stability. In this work, 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphoethanolamine (DTPE) is used as a photo-polymerizable lipid to form functional hybrid-liposomes as it can form intermolecular cross-linking through the diacetylenic groups. Hybrid-liposomes were formulated using mixtures of DTPE and saturated lipids of different chain lengths (dipalmitoylphosphatidylcholine (DPPC) and dimirystoilphosphatidylcholine (DMPC)) at different molar ratios. The physico-chemical characteristics of the liposomes has been studied before and after UV irradiation using a combination of techniques: DSC, QCM-D and solid-state NMR. The results signify the importance of a subtle modification in alkyl chain length on the phase behavior of the hybrid-liposomes and on the degree of crosslinking in the shell.