par Brocas, Huguette;Promel, Robert 
Référence Bulletin des Sociétés chimiques belges, 77, 1-2, page (103-108)
Publication Publié, 1968
Référence Bulletin des Sociétés chimiques belges, 77, 1-2, page (103-108)
Publication Publié, 1968
Article révisé par les pairs
| Résumé : | Two new analogs (III and VII) of succinoadenine have been synthesized. Starting from 7‐chlorothiazolo[5,4‐d]pyrimidine (I), the first one has been prepared by reaction with diethyl D,L‐aspartate, followed by alkaline hydrolysis. On the other hand, direct amination of 7‐methylthiothiazolo[5,4‐d]pyrimidine (IV) with D,L‐aspartic acid has given a product formulated as 5‐formamido‐4‐mercapto‐6‐methylthiopyrimidine (V). An authentic specimen has been prepared for comparison by formylation of 5‐amino‐4‐chloro‐6‐methylthiopyrimidine (VIII) and replacement of the chlorine atom with sodium hydrosulfide. The second analog has been obtained either by reaction of 7‐chlorothiazolo[5,4‐d] pyrimidine (I) with D,L‐mercaptosuccinic acid or by alkylation of 7‐mercapto‐thiazolo[5,4‐d]pyrimidine (VI) with D,L‐bromosuccinic acid. Copyright © 1968 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim |
