Résumé : The present paper shows an in-depth numerical characterisation of the Jetin Hot Co-flow (JHC) configuration using the Reynolds Averaged Navier-Stokes (RANS) modelling with detailed chemistry. The JHC burner emu-lates the MILD combustion by means of a hot and diluted co-flow and highspeed injection. The current investigation focuses on the effect of turbu-lent combustion models, turbulence model parameters, boundary conditions,multi-component molecular diffusion and kinetic mechanisms on the results.Results show that the approaches used to model the reaction fine structures,namely as Perfectly Stirred Reactors (PSR) or Plug Flow Reactors (PFR),do not have a major impact on the results. Similarly, increasing the com-plexity of the kinetic mechanism does not lead to major improvements on thenumerical predictions. On the other hand, the inclusion of multi-componentmolecular diffusion helps increasing the prediction accuracy. Three differentEddy Dissipation Concept (EDC) model formulations are compared, showingtheir interaction with the choice of the C1eps constant in the k −eps turbulencemodel. Finally, two approaches are benchmarked for turbulence-chemistryinteractions, the EDC model and the Partially Stirred Reactor (PaSR) model.