par Willems, Glenda 
;Gepts, Willy ;Bremer, Antoine
Référence American Journal of Digestive Diseases, 22, 5, page (419-423)
Publication Publié, 1977
;Gepts, Willy ;Bremer, Antoine Référence American Journal of Digestive Diseases, 22, 5, page (419-423)
Publication Publié, 1977
Article révisé par les pairs
| Résumé : | Endogenous hypergastrinemia (P<0.01) was produced in 4 dogs with a Heidenhain pouch through surgical exclusion of the pyloric antrum. This was followed by acid hypersecretion and increased DNA synthesis and mitotic activity (P<0.01) in the mucosa of the Heidenhain pouch. The acid hypersecretion induced by histamine in beeswax in 4 other dogs did not increase the proliferative parameters in the pouch mucosa of the latter. A positive correlation (r=0.84, P<0.01) was found between the serum gastrin levels and the DNA synthesis index values measured in the 4 animals before antral exclusion, after antral exclusion, and after antrectomy. These data support the hypothesis that the trophic effect of gastrin on the fundic mucosa can be elicited by physiological doses of endogenous hormone. © 1977 Digestive Disease Systems, Inc. |
