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Immune responses after intralymphatic injection of ³²p-chromium phosphate in the dog

par Toussaint, Charles ;Kinnaert, Paul ;Elias, M.
Référence European surgical research, 1, 1, page (37-49)
Publication Publié, 1969

Article révisé par les pairs

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Résumé :

Intralymphatic injection of 7-10 mC colloidal 32P-chromium phosphate in dogs induces profound and persistent lymphopenia, destruction of directly exposed lymph nodes, and variable degrees of lymphocyte depletion in remote lymph nodes and spleen. Radiophosphorus uptake is extremely high in liver, spleen, and in directly exposed lymph nodes, negligible in bones, lungs and remote lymph nodes. These data suggest that lymphopenia and lymphocyte depletion in remote lymph nodes is caused by irradiation of the blood within the liver. In 32P-treated dogs, the synthesis of antibodies against human serum albumin is deeply depressed, but this immunodepressive therapy does not prolonge kidney allograft survival. The hepatic lesions observed in the irradiated dogs contraindicate the use of 32P as immunodepressive mean in human organ transplantation. © 1969 S. Karger AG, Basel.