par Vandermeers-Piret, Marie-Claire 
;Camus, Jean Claude ;Christophe, Jean
Référence European journal of biochemistry / FEBS, 4, 3, page (334-339)
Publication Publié, 1968
;Camus, Jean Claude ;Christophe, Jean Référence European journal of biochemistry / FEBS, 4, 3, page (334-339)
Publication Publié, 1968
Article révisé par les pairs
| Résumé : | The free and total activities of four acid hydrolases were assayed in the liver of young rats during the 3 days period following the end of a lysine and threonine deficiency. There is a slight decrease at 15 h in the total activities of deoxyribonuclease, ribonuclease, β‐glycerophosphatase and β‐glucuronidase, on a wet weight tissue basis. These activities get back to starting values later on, except for deoxyribonuclease which has risen by a factor of 1.8 after 3 days. Free activities expressed as percentages of total activities increase more or less rapidly and steadily during the recovery period. The free activity of deoxyribonuclease has augmented after 2 and 3 days; that of β‐glucuronidase rises already after 15 h and stays elevated for 3 days; that of the other hydrolases is above the starting level only at the end of the first day. These data suggest a labilization of the lysosomes and a net synthesis of acid deoxyribonuclease. The possible effects of these modifications of hepatic lysosomes on the first mitotic wave and on the other cellular alterations which follow the end of protein malnutrition are discussed. Copyright © 1968, Wiley Blackwell. All rights reserved |
