Résumé : The interface between protected and communal lands presents certain challenges for wildlife conservation and the sustainability of local livelihoods. This is a particular case in South Africa, where foot-and-mouth disease (FMD), mainly carried by African buffalo (Syncerus caffer) is transmitted to cattle despite a fence surrounding the protected areas.The ultimate objective of this thesis was to improve knowledge of FMD transmission risk by analyzing behavioral patterns of African buffalo and cattle near the Kruger National Park, and by modelling at fine spatial scale the seasonal risk of contact between them. Since vegetation is considered as a primary bottom-up regulator of grazers distribution, I developed fine-scale seasonal mapping of vegetation. With that purpose, I explored the utility of WorldView-2 (WV-2) sensor, comparing object- (OBIA) and pixel-based image classification methods, and various traditional and advanced classification algorithms. All tested methods produced relatively high accuracy results (>77%), however OBIA with random forest and support vector machines performed significantly better, particularly for wet season imagery (93%).In order to investigate the buffalo and cattle seasonal home ranges and resource utilization distributions I combined the telemetry data with fine-scale maps on forage (vegetation components, and forage quality and quantity). I found that buffalo behaved more like bulk feeders at the scale of home ranges but were more selective within their home range, preferring quality forage over quantity. In contrast, cattle selected forage with higher quantity and quality during the dry season but behaved like bulk grazers in the wet season.Based on the resource utilization models, I generated seasonal cost (resistance) surfaces of buffalo and cattle movement through the landscape considering various scenarios. These surfaces were used to predict buffalo and cattle dispersal routes by applying a cumulative resistant kernels method. The final seasonal contact risks maps were developed by intersecting the cumulative resistant kernels layers of both species and by averaging all scenarios. The maps revealed important seasonal differences in the contact risk, with higher risk in the dry season and hotspots along a main river and the weakest parts of the fence. Results of this study can guide local decision makers in the allocation of resources for FMD mitigation efforts and provide guidelines to minimize overgrazing.