• Citer

Variations of cytotoxic antibodies to cells with herpes simplex virus antigens in women with progressing or regressing cancerous lesions of the cervix

par Thiry, Lise ;Sprecher-Goldberger, Suzanne;Fassin, Yves ;Gould, I.;Gompel, Claude ;Pestiau, J.;De Halleux, Francis
Référence American journal of epidemiology, 100, 4, page (251-261)
Publication Publié, 1974-10

Article révisé par les pairs

• Détails
• Contenu

Résumé :

Thiry, L. (Institut Pasteur du Brabant, Brussels, 1040 Belgium), S. Sprecher- Goldberger. Y. Fassin, I. Gould, C. Gompel, J. Pestiau and F. De Halleux. Variations of cytotoxic antibodies to cells with herpes simplex virus antigens in women with progressing or regressing cancerous lesions of the cervix. Am J Epidemiol 100:261-261, 1974.-Antibodies to herpes simplex virus antigens were followed for a period of 3 to 30 months in 126 women attending a center for detection of cancer. Neutralizing antibodies to herpes simplex type 2 virus (HSV-2) did not vary in 96% of the women with normal cervical smears, and complement dependent cytotoxic antibodies to HSV-2 infected cells were stable in 81% of these women. The variations were frequent in women with pathologic smears and the two types of antibodies often did not vary in a parallel direction. Of 18 women with progressing cervical lesions, 89% had high or increasing neutralizing antibody titers and, in contrast, 83% had decreasing or no serum cytolytic activities. Of 60 women who were treated for cervical carcinoma, or who apparently were spontaneously cured from dysplasia or carcinoma in situ, 60% showed an increase of cytolytic activity after treatment or when the cervical smear spontaneously became normal; only 15% of these women showed an increase of neutralizing antibodies. Sera plus complement assayed on a HSV-2 transformed cell line had lower cytolytic activities than on HSV-2 infected cells, but the variations of activities were most often parallel on the two cell cultures. The results confirm previous indications that neutralizing antibody titers are related to the evolution of precancerous and cancerous lesions of the cervix; in addition, they are in agreement with reports on other tumors, showing that the antibodies to surface antigens vary inversely with the severity of the lesions. © 1975 by The School of Hygiene and Public Health of The Johns Hopkins University.