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Molecular basis for modulated regulation of gene expression in the arginine regulon of Escherichia coli K-12

par Cunin, Raymond ;Eckhardt, Thomas;Piette, Jacques;Boyen, Anne;Pierard, André ;Glansdorff, Nicolas
Référence Nucleic acids research, 11, 15, page (5007-5019)
Publication Publié, 1983-08

Article révisé par les pairs

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Résumé :

We compare the nucleotide sequences of the regulatory regions of five genes or groups of genes of the arginine regulon of Escherichia coli K-12 : argF, argI, argR, the bipolar argECBH operon and the carAB operon. All these regions harbour one or two copies of a conserved 18 bp sequence which appears to constitute the basic arginine operator sequence (ARG box) . We discuss the influence of ARG box copy number, degree of dyad symmetry, base composition, and position relative to the cognate promoter site on the derepression-repression ratios of the genes of the regulon. A novel hypothesis, based on structural considerations, is also put forward to account for the absence ot attenuation control. © 1983 IRL Press Limited.