par De Deken, R.H. 
Référence Biochimica et biophysica acta, 17, C, page (494-502)
Publication Publié, 1955
Référence Biochimica et biophysica acta, 17, C, page (494-502)
Publication Publié, 1955
Article révisé par les pairs
| Résumé : | The inhibition of the phosphorylations and the fermentation of yeast resulting from the action of numerous nitro- and halophenols was measured. The relations existing between molecular structure and biological activity are outlined. The inhibition power is a function of the mobility of the proton: a low pK is favourable, whereas chelation with a ring substituent in ortho position weakens the inhibitory activity. Two other factors act on the penetration of the molecules into the cell: a low extracellular pH is favourable, since the phenols penetrate as undissociated molecules, and a high liposolubility of the derivative also facilitates its penetration. The measured inhibition is the resultant of these factors. © 1995. |
