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Spontaneous diabetes in dogs and cats - A pathological study

par Gepts, Willy ;Toussaint, Daniel
Référence Diabetologia, 3, 2, page (249-265)
Publication Publié, 1967-04

Article révisé par les pairs

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Résumé :

A histological study of 30 spontaneously diabetic dogs and 5 spontaneously diabetic cats is presented. - The islets of Langerhans and the B cells were strongly reduced in number in a large majority of the diabetic dogs. The B cells were often degranulated and hydropic. In cases of longer duration, the islets were scarce and B cells could no longer be found. - In contrast to the findings in diabetic dogs, all five cats showed numerous islets and B cells. However in 4 cats, the B cells showed complete degranulation and hydropic changes, as in the dogs. In one cat, the B cells had a normal appearance. Extensive hyalin deposits were found in the stroma of the islets in 2 cats. In one cat, an islet showed a dense lymphocytic infiltration. - No lesions identical to human diabetic glomerulosclerosis were found in any of the dogs or cats. The changes most frequently observed were a variable degree of thickening of the mesangial stalk of the glomerular capillaries, and an hypertrophy of the wall of the afferent arteriole. Scars resulting from chronic pyelonephritis, were found in a few dogs and cats. - Acellular, non-functional capillaries, with degeneration of pericytes ("ghost-cells") were found in larger numbers in the retinas of the diabetic dogs than in non-diabetic control dogs. A very few microaneurysms could be found in 3 dogs. The lower incidence of the most typical lesions of diabetic retinopathy in dogs, as compared with the human diabetic, is probably related to the shorter duration of the disease in these animals. However, a lower susceptibility of the retina of dogs and cats to develop degenerative changes cannot be excluded. - A severe steatosis was observed in the liver of many dogs and cats. In 4 dogs, the liver showed early cirrhosis. In diabetic dogs and cats, the adrenal cortex often showed hypertrophy and contained adenomas; however, these changes have also been reported in non-diabetic aging dogs. An adenoma was found in 2 of the 7 pituitaries obtained from diabetic dogs; the cytological aspect of these adenomas and of the pituitaries will be reported in a later publication. © 1967 Springer-Verlag.