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Discharge of newly synthesized proteins in pure juice collected from the human pancreas. Indication of more than one pool of intracellular digestive enzymes

par Robberecht, Patrick ;Cremer, Michel ;Christophe, Jean
Référence Gastroenterology, 72, 3, page (417-420)
Publication Publié, 1977

Article révisé par les pairs

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Résumé :

The pancreatic secretion of 6 normal human volunteers was collected by endoscopic cannulation of the main pancreatic duct. The appearance of newly synthesized proteins was monitored at 1 min intervals after labeling with [75Se]methionine. The minimum transit time of these proteins from their site of synthesis to the acinas lumen was 36 ± 8 min. Stimulation of protein secretion by a rapid intravenous injection of caerulein (40 ng per kg), 1 hr after [75Se]methionine administration, greatly decreased (by 73% on an average) the specific radioactivity of the discharged proteins. These data support the concept of a functional heterogeneity of proteins secreted by the human pancreas.