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Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression

par Erkens, Mirthe;Tanaka-Yamamoto, Keiko;Chéron, Guy ;Márquez-Ruiz, Javier;Prigogine, Cynthia ;Schepens, Jan Tg;Nadif Kasri, Nael;Augustine, George G.J.;Hendriks, Wiljan Jaj
Référence Molecular Brain, 8, page (1)
Publication Publié, 2015-01

Article révisé par les pairs

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Résumé :

BACKGROUND: Regulation of synaptic connectivity, including long-term depression (LTD), allows proper tuning of cellular signalling processes within brain circuitry. In the cerebellum, a key centre for motor coordination, a positive feedback loop that includes mitogen-activated protein kinases (MAPKs) is required for proper temporal control of LTD at cerebellar Purkinje cell synapses. Here we report that the tyrosine-specific MAPK-phosphatase PTPRR plays a role in coordinating the activity of this regulatory loop.