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The transcription factor c-Maf promotes the differentiation of follicular helper T cells

par Andris, Fabienne ;Denanglaire, Sébastien ;Anciaux, Maëlle ;Hercor, Mélanie ;Hussein, Hind ;Leo, Oberdan
Référence Frontiers in immunology, 8, APR, 480
Publication Publié, 2017-04

Article révisé par les pairs

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Résumé :

Follicular helper T cells (Tfh) have been identified as the primary cell subpopulation regulating B cell responses in germinal centers, thus supporting high-affinity antibody production. Among the transcription factors orchestrating Tfh cell differentiation and function, the role played by the proto-oncogene c-Maf remains poorly characterized. We report herein that selective loss of c-Maf expression in the T cell compartment results in defective development of Tfh cells in response to both antigen/adjuvant vaccinations and commensal intestinal bacteria. Accordingly,c-Maf expression in T cells was essential for the development and high-affinity antibody secretion in vaccinated animals. c-Maf was expressed early, concomitantly to BCL6, in Tfh cell precursors and found to regulate Tfh fate in a cell-autonomous fashion. Altogether, our findings reveal a novel, non-redundant, function for c-Maf in the differentiation of Tfh cells and the regulation of humoral immune responses to T-cell-dependent antigens.