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Thyroid auto-immune disease and thyroid function in families of subjects with down’s syndrome

par Vanhaelst, Luc ;Hayez, F.;Bonnyns, Marc ;Bastenie, Paul Auguste
Référence The Journal of clinical endocrinology and metabolism, 30, 6, page (792-797)
Publication Publié, 1970

Article révisé par les pairs

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Résumé :

In families of children affected with Down’s syndrome, the mothers show an increased frequency of clinical thyroid disorders; the fathers, the mothers, the siblings and the affected children present with a high incidence of thyroid autoantibodies and of an unusual pattern of the serum iodinated proteins. This is characterized by a normal PBI, a decreased BEI and a greatly increased butanol insoluble fraction (NBEI). The elevated serum NBEI level is probably a genetic trait. In the affected parents, it may correspond to an increased risk for chromosomal disturbances in the offspring. © 1970 by The Endocrine Society.