par Vergote, Vibeke;Schroyens, Wilfried;Debussche, Sarah;Maertens, Vincent;Beel, Karolien;Lemmens, Jan;Caron, Charlotte;Delrieu, Vanessa ;Van Den Broeck, Isabelle;Vanstraelen, Gaetan;Jacquy, Caroline ;Janssens, Ann;Schauvlieghe, Liesbeth;De Samblanx, Hadewijch;Madoe, Vincent;Meers, Stef;Boulet, Dominique;Verhoef, Gregor E G;van Hoof, Achiel;André, Marc;Bonnet, Christophe;Van Hende, Vanessa;Van Den Neste, Eric;Van Eygen, Koen;Maerevoet, Marie ;Pranger, Delphine
Référence Acta Clinica Belgica (English ed. Printed), 72, 3, page (172-178)
Publication Publié, 2017-05
Référence Acta Clinica Belgica (English ed. Printed), 72, 3, page (172-178)
Publication Publié, 2017-05
Article révisé par les pairs
Résumé : | Introduction: Mantle cell lymphoma is a B-cell non-Hodgkin’s lymphoma characterized by a t(11;14), resulting in overexpression of cyclin D1. Conventional chemotherapy obtains frequent (but short) remissions, leading to a poor median overall survival (OS) of 3–5 years. To obtain more information about the prevalence and current treatment of Mantle cell lymphoma (MCL) in Belgium, we collected data in a Belgian registry of MCL. Materials and methods: All Belgian MCL patients, t(11;14) and/or cyclin D1 positive, seen in hematology departments over a one-year period (April 2013–March 2014) were included. Data about patient characteristics, histology, treatment lines, and response were compiled and retrospectively analyzed. Results: Four hundred and four patients were included with a median age at diagnosis of 64 years (range 23–96 years) and a male predominance (72%). For 2013, we calculated a prevalence of at least 36.2 per million and an incidence of at least 7.0 per million in the Belgian population. Characteristics at diagnosis involved lymphadenopathy (82%), splenomegaly (44%), B-symptoms (39%), and hepatomegaly (10%). Bone marrow invasion was present at diagnosis in 77%. Stage at diagnosis was advanced in the majority of cases. The median number of treatment lines was 1. Type of first line treatment included a combination of anthracyclin and cytarabine-based regimen (34%), anthracyclin (39%), and other. Rituximab was used in 88% of first line treatments. In 44% first line treatment was followed by autologous stem cell transplantation. Conclusion: The analysis of this Belgian MCL registry provides insight in the epidemiology, demographics, and current treatment of our Belgian MCL population. |