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One-Step Synthesis of a Unique Molecular Platform for the Selective Functionalization of Calix[6]arenes

par Lavendomme, Roy ;Malytskyi, Volodymyr ;Vandermeersch, Jeremy;Luhmer, Michel ;Jabin, Ivan
Référence Synthesis, 49, 05, page (1009-1023)
Publication Publié, 2017

Article révisé par les pairs

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Résumé :

High selectivity is crucial for the functionalization of macrocyclic platforms bearing multiple identical functions. In the case of calix[6]arenes, only a few examples of efficient homo-functionalization have been reported. Herein, we describe the one-step synthesis of a tri-differentiated calix[6]arene and its use as a key intermediate to selectively access various homo- and hetero-functionalization patterns. In combination with the ‘all-but-one’ carbamatation methodology, this unique building block gives access to sophisticated calix[6]arenes that, until now, were inaccessible.