par Soubhye, Jalal 
;Gelbcke, Michel ;Van Antwerpen, Pierre ;Dufrasne, François ;Boufadi, Yasmina Mokhtaria;Neve, Jean ;Furtmüller, Paul G;Obinger, Christian;Zouaoui Boudjeltia, Karim ;Meyer, Franck
Référence ACS Medicinal Chemistry Letters, 8, 2, page (206-210)
Publication Publié, 2017-02
;Gelbcke, Michel ;Van Antwerpen, Pierre ;Dufrasne, François ;Boufadi, Yasmina Mokhtaria;Neve, Jean ;Furtmüller, Paul G;Obinger, Christian;Zouaoui Boudjeltia, Karim ;Meyer, Franck Référence ACS Medicinal Chemistry Letters, 8, 2, page (206-210)
Publication Publié, 2017-02
Article révisé par les pairs
| Résumé : | The implementation of dynamic combinatorial libraries allowed the determination of highly active reversible and irreversible inhibitors of myeloperoxidase (MPO) at the nanomolar level. Docking experiments highlighted the interaction between the most active ligands and MPO, and further kinetic studies defined the mode of inhibition of these compounds. Finally, in vivo evaluation showed that one dose of irreversible inhibitors is able to suppress the activity of MPO after inducing inflammation. |
