par Born, Sidney;Kitahara, Kazuo
Référence International journal of quantum chemistry, 9, 2 S, page (237-257)
Publication Publié, 1975
Article révisé par les pairs
Résumé : A discussion of the microscopic components of the membrane demonstrates the relation between the upwards and downwards position of a membrane dipole and the permeability of a segment of interconnected protein subunits. In the model which is proposed, the membrane is assumed to consist of a continuous system of idealized dipoles which have two equilibrium positions, one parallel and one antiparallel to the normal membrane surface. An analogy is made with a magnetic system of Ising spins in a magnetic field. The dynamics of the Ising spin system is then discussed and the results summarized. These results are then used to propose a formula for the sodium conductivity for the equivalent system of dipole channels in the membrane in terms of the fluctuation of these dipoles around the average polarization. The sodium conductance is shown to depend on the rigidity of the channel structure in the presence of an electric field. The results of the numerical calculation based on this model show qualitative agreement with the experimental results of Hodgkin and Huxley's measurements of the sodium current. Copyright © 1975 John Wiley & Sons, Inc.