Somatic mutation, copy number and transcriptomic profiles of primary and matched metastatic estrogen receptor-positive breast cancers.

Fumagalli, Debora; Wilson, T R; Salgado, Roberto; Lu, X; Yu, J; O'Brien, CO; Walter, K; Huw, L Y; Criscitiello, Carmen; Laïos, Ioanna; Jose, Vinu; Brown, David Norman; Rothé, Françoise; Maetens, Marion M.; Zardavas, Dimitrios; Savas, P; Larsimont, Denis; Piccart-Gebhart, Martine; Michiels, Stefan; Lackner, Mark; Sotiriou, Christos; Loi, Sherene

doi:doi/10.1093/annonc/mdw286

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Somatic mutation, copy number and transcriptomic profiles of primary and matched metastatic estrogen receptor-positive breast cancers.

par Fumagalli, Debora

;Wilson, T R ;Salgado, Roberto ;Lu, X ;Yu, J ;O'Brien, CO ;Walter, K ;Huw, L Y ;Criscitiello, Carmen

;Laïos, Ioanna ;Jose, Vinu

;Savas, P ;Larsimont, Denis

;Piccart-Gebhart, Martine

;Michiels, Stefan

;Lackner, Mark ;Sotiriou, Christos

;Loi, Sherene

Référence Annals of oncology, 27, 10, page (1860-1866)
Publication Publié, 2016-10

Article révisé par les pairs

Résumé :

Estrogen receptor-positive (ER+) breast cancers (BCs) constitute the most frequent BC subtype. The molecular landscape of ER+ relapsed disease is not well characterized. In this study, we aimed to describe the genomic evolution between primary (P) and matched metastatic (M) ER+ BCs after failure of adjuvant therapy.

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