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Quantitative 31P MRS of the normal adult human brain. Assessment of interindividual differences and ageing effects

par Longo, Renata;Ricci, Claudio;Palma, Ludovico Dalla;Vidimari, Rossella;Giorgini, Adelma;Den Hollander, Jan;Segebarth, Christoph
Référence NMR in biomedicine, 6, 1, page (53-57)
Publication Publié, 1993

Article révisé par les pairs

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Résumé :

The characteristics of the 31P MR spectra from a large central volume in the brain of 47 healthy adults (aged 25–85 years) were assessed. Spectral parameters were estimated by means of a time‐domain fitting technique. Statistical uncertainties of the estimates were determined by means of the Cramer‐Rao theory and minimized by introducing a priori knowledge into the fitting procedure. Age‐dependency of the spectral parameters was assessed by means of linear regression. Significant differences between individuals were established for some parameters. A significant age‐dependency (p⩽0.001) of ca 20% over the age range considered was found for the intensity of the phosphocreatine resonance line. Copyright © 1993 John Wiley & Sons, Ltd.