par Balasse, Edmond 
Référence European journal of clinical investigation, 1, 3, page (155-160)
Publication Publié, 1970
Référence European journal of clinical investigation, 1, 3, page (155-160)
Publication Publié, 1970
Article révisé par les pairs
| Résumé : | Abstract The rate of turnover and oxidation of plasma free fatty acids (FITA) was measured in 7 normal anaesthetized dogs infused at a constant rate with l‐14C‐palmitate for 5 h. After a control period, sustained hyperketonaemia was induced by infusing sodium aceto‐acetate (AA). This produced a fall in plasma FFA (33%) and in blood sugar (24%), without changes in immuno‐reactive insulin (IRI) concentrations. During the control period, the turnover rate of carbon of FFA averaged 131 μat./kg/min, 32% of which were oxidized, thus supplying 17.7% of the total CO2 production. At the end of the AA infusion, the mean turnover rate of FFA was reduced to 75μat.C/kg/min; since only 13.9 % of these were oxidized, the contribution of FFA to total CO2 production was reduced to 4.3%. In the light of previous work showing that ketone infusions also reduce the rate of turnover and oxidation of glucose in dogs, we conclude that, under appropriate experimental conditions, ketones may strongly reduce the role of FFA and glucose as sources of energy. Copyright © 1970, Wiley Blackwell. All rights reserved |
