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Correlation of extrusion forces, raw materials and sphere characteristics

par Baert, Lieven;FANARA, D.;Remon, Jean Paul;Massart, Désiré Luc
Référence Journal of Pharmacy and Pharmacology, 44, 8, page (676-678)
Publication Publié, 1992

Article révisé par les pairs

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Résumé :

Abstract— This communication reports on the correlation between extrusion forces and sphere characteristics. Dicalcium phosphate dihydrate, α‐lactose monohydrate and anhydrous β‐lactose were models for respectively an insoluble, a medium soluble and a highly soluble drug and were used to produce spheres. Phase diagrams for ternary mixtures consisting of microcrystalline cellulose, water and a third excipient were constructed. The region where good spheres were obtained correlated well with the area of extrusion forces between 630 and 1260 N. This correlation was seen for the insoluble, the medium and the highly soluble products. 1992 Royal Pharmaceutical Society of Great Britain