• Citer

Synthesis, Spectroscopic Characterization and Antitumour Activity of Diorganotin(IV) Derivatives of N‐Substituted Ortho‐Aminobenzoic Acid

par Meriem, Abdelkader ;Biesemans, Monique;Willem, Rudolph ;Mahieu, Bernard;De Vos, Dick;Lelieveld, Peter;Gielen, Marcel
Référence Bulletin des Sociétés chimiques belges, 100, 5, page (367-374)
Publication Publié, 1991

Article révisé par les pairs

• Détails
• Contenu

Résumé :

Four compounds of the type [(o‐RNH‐C6H4COO)(CH3CH2CH2CH2)2Sn]2O and [(o‐CH3NH‐C6H4COO)(CH3)2Sn]2O have been prepared, characterized by 1H, 13C, 119Sn NMR, and by Mössbauer and mass spectrometry. They have been tested in vitro against two human tumour cell lines, nl. MCF‐7 (mammary tumour) and WiDr (colon carcinoma), and found to score slightly better than cis‐platin but markedly less than other cytostatic agents. Copyright © 1991 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim