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Exceptionally high in vitro antitumor activity of substituted triphenyltin benzoates including salicylates against a human mammary tumor, MCF‐7, and a colon carcinoma, WiDr

par Gielen, Marcel ;Willem, Rudolph ;Biesemans, Monique;Boualam, Mohammed ;Khloufi, Abdelaziz El;De Vos, Dick
Référence Applied organometallic chemistry, 6, 3, page (287-291)
Publication Publié, 1992

Article révisé par les pairs

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Résumé :

Nine new substituted triphenyltin benzoates of the type Ar3SnOOCC6H2XYZ [X = Y = H, Z = 2‐OCH3 and 4‐F; X = H, Y = 3‐F, Z = 5‐F; X = H, Y = 2‐OH, Z = 5‐Cl, 5‐NH2, 5‐OCH3 and 5‐SO3H; X = 2‐OH, Y = 3‐CH(CH3)2 and Z = 5‐CH(CH3)2] were prepared and possess considerable in vitro antitumor activity against two human tumor cell lines (MCF‐7, a mammary tumor, and WiDr, a colon carcinoma) comparable with that of mitomycin C. Copyright © 1992 John Wiley & Sons Ltd.