Article révisé par les pairs
Résumé : About 30 analogues of BAPTA‐AM, a potential antithrombotic agent, have been synthesized and tested for their effect on the production of prostacyclin. None of them was found to be a better enhancer of the production of prostacyclin by aortic endothelial cells than BAPTA‐AM itself. The enhancing effect can be produced by compounds unable to chelate Ca2+, thus confirming that it is not related to their buffering capacity for free Ca2+. Copyright © 1994 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim