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Effective tranexamic acid concentration for 95% inhibition of tissue-type plasminogen activator induced hyperfibrinolysis in children with congenital heart disease: A prospective, controlled, in-vitro study

par Rozen, Laurence ;Faraoni, David ;Sanchez Torres, Cristel ;Willems, Ariane ;Noubouossié, Denis;Barglazan, Dragos;Van Der Linden, Philippe ;Demulder, Anne
Référence European journal of anaesthesiology, 32, 12, page (844-850)
Publication Publié, 2015-12

Article révisé par les pairs

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Résumé :

BACKGROUND: Although recent studies have assessed tranexamic acid (TXA) pharmacokinetics in different subgroups, the effective concentration of TXA required to completely inhibit fibrinolysis remains to be determined.