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Controlled Clinical Trial of L-Dopa and Nafoxidine in Advanced breast Cancer: An E.O.R.T.C. Study

par Heuson, Jean-Claude ;Blonk-Van Der Wijst, J.;Drochmans, Alfons;Maass, Heinrich;Cheix, Françoise;Sobrinho, Luís Gonçalves;Nowakowski, H.
Référence British medical journal, 2, 5973, page (714-715)
Publication Publié, 1975-06

Article révisé par les pairs

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Résumé :

L-Dopa lowers plasma prolactin levels, and there have been reports that patients with advanced breast cancer have been successfully treated with L-dopa. To test the potential value of L-dopa in this disease a randomized clinical trial of L-dopa and nafoxidine (as the reference compound) was conducted in postmenopausal women with advanced breast cancer. Objective remissions were obtained in seven out of 36 patients (19%) treated with nafoxidine but in none out of 40 patients treated with L-dopa. L-Dopa in the dose schedule used seems to be ineffective in advanced breast cancer. © 1975, British Medical Journal Publishing Group. All rights reserved.