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Endothélium et microcirculation au cours des états critiques. Actes du séminaire de recherche translationnelle de la Société de réanimation de langue française (1er décembre 2015)

par Ait-Oufella, Hafid;Tamion, Fabienne;Gibot, Sébastien;Guillon, Antoine;Mira, Jean-Paul;Monneret, Guillaume;Pène, Frédéric;Sharshar, Tarek;Taccone, Fabio ;Textoris, Julien
Référence Réanimation, 25, 4, page (431-439)
Publication Publié, 2016-07

Article révisé par les pairs

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Résumé :

Under physiological conditions, the endothelium regulates vasomotor tone, the coagulation cascade, platelet aggregation, and vascular permeability. Endothelial cells have common properties, but these vascular cells also have organ-related characteristics, defining the endothelial heterogeneity. Endothelial dysfunction has been associated with many pathophysiological processes such as inflammation and oxidative stress. Impaired endothelial function leads to phenotypic changes and is involved in the pathophysiology of organ failure during critical conditions. The development of accurate tools for the early detection of endothelial dysfunction and microcirculatory hypoperfusion could be of great interest in critically ill patients.