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4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion

par Pirotte, Bernard ;Florence, Xavier ;Goffin, Eric;Medeiros, Marlen Borges;de Tullio, Pascal;Lebrun, Philippe
Référence European journal of medicinal chemistry, 121, page (338-351)
Publication Publié, 2016-10

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Titre:	4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion
Auteur:	Pirotte, Bernard; Florence, Xavier; Goffin, Eric; Medeiros, Marlen Borges; de Tullio, Pascal; Lebrun, Philippe
Informations sur la publication:	European journal of medicinal chemistry, 121, page (338-351)
Statut de publication:	Publié, 2016-10
Sujet CREF:	Pharmacologie
	Chimie organique
Mots-clés:	2,2-Dimethylchromans
	ATP-Sensitive potassium channels
	Cromakalim analogs
	Insulin secretion
	Potassium channel openers
	Smooth muscle contractile activity
Note générale:	SCOPUS: ar.j
Langue:	Anglais
Identificateurs:	urn:issn:0223-5234
	info:doi/10.1016/j.ejmech.2016.05.042
	info:pii/S0223523416304408
	info:scp/84973121715
	info:pmid/27267004