par Wang, Jianjun 
;Evano, Gwilherm
Référence Organic letters, 18, 15, page (3542-3545)
Publication Publié, 2016
;Evano, Gwilherm Référence Organic letters, 18, 15, page (3542-3545)
Publication Publié, 2016
Article révisé par les pairs
| Résumé : | An efficient asymmetric total synthesis of the dimeric macrocyclic diaryl ether phenethyltetrahydroisoquinoline alkaloid (-)-melanthiodine is reported. Key steps of the synthesis include an efficient Noyori asymmetric transfer hydrogenation to access the enantioenriched phenethyltetrahydroisoquinoline monomeric subunit and a copper-mediated cyclodimerization to form the two diaryl ether linkages with concomitant macrocyclization. |
