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Endotracheal gentamicin for the prevention of bronchial infections in patients with tracheotomy

par Klastersky, Jean ;Cappel, Roger ;Noterman, Jacques ;Snoeck, Jean-Marc ;Geuning, Christiane;Mouawad, Émile
Référence Internationale Zeitschrift für klinische Pharmakologie, Therapie, und Toxikologie, 7, 4, page (279-286)
Publication Publié, 1973

Article révisé par les pairs

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Résumé :

Endotracheal administration of gentamicin has been compared with saline injections in tracheotomized patients. Endotracheal administration of gentamicin significantly reduced the incidence of colonization of the tracheal secretions by gram negative rods (p> 0.01) and the frequency of the administration of systemic antibiotics for the treatment of bacteriologically proven infections (p > 0.01). The data also suggest that gentamicin treated patients presented a lower incidence of urinary tract infections, bacteremias and septic deaths than controls. Bacteria isolated from patients treated with endotracheal gentamicin were more resistant to gentamicin than microorganisms recovered from the respiratory tract of saline treated controls. Since emergence of gentamicin resistant organisms during endotracheal administration of gentamicin to tracheotomized patients might limit the usefulness of this type of therapy, further controlled studies are needed to assess its importance.