par Van Der Auwera, Philippe 
;Matsumoto, Takahiro;Husson, Mireille
Référence Journal of antimicrobial chemotherapy, 22, 2, page (185-192)
Publication Publié, 1988-08
;Matsumoto, Takahiro;Husson, Mireille Référence Journal of antimicrobial chemotherapy, 22, 2, page (185-192)
Publication Publié, 1988-08
Article révisé par les pairs
| Résumé : | The penetration of several antibiotics into human polymorphonuclear leucocytes was measured with a bioassay. The aminoglycosides (gentamicin, netilmicin), oxacillin and LY146032, a new lipopeptidic antibiotic, had a penetration which was generally less than 60%, whereas new fluoro-quinolones (enoxacin, ciprofloxacin, CI934, Ro236240) and rifamycins (rifampicin, LM427) were concentrated 2.4 to 14.2-fold. The concentration of vancomycin and teicoplanin associated with the neutrophils appeared to be saturable over the range of extracellular concentrations tested (5-20 mg/l). Coumermycin, an inhibitor of DNA-gyrase, was highly concentrated (11.3 to 16.6-fold) within the neutrophils. The penetration of clindamycin and erythromycin was low (0.60- to 1.48-fold). © 1988, by The British Society for Antimicrobial Chemotherapy. |
