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N-(Phosphonacetyl)-l-aspartate (PALA) in advanced breast cancer: a phase II trial of the EORTC breast cancer cooperative group

par Paridaens, R. ;Mouridsen, Henning H.T.;Palshof, Torben;Cocconi, Giorgio;van Oosterom, Allan A.T.;Rotmensz, Nicole;Sylvester, Richard J. ;Heuson, Jean-Claude ;Rozencweig, Marcel
Référence European journal of cancer & clinical oncology, 18, 1, page (67-70)
Publication Publié, 1982

Article révisé par les pairs

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Résumé :

Twenty-nine evaluable patients with extensively pretreated breast cancer received PALA, a new pyrimidine antimetabolite. The drug was given by intravenous infusion over 60 min, at a daily dose of 2.5 g/m2 for 2 consecutive days. Courses were repeated at 2-week intervals and doses were escalated to toxicity. Two objective partial remissions were observed, lasting for 3 and 4.5 months respectively. Toxic effects were dose-related and consisted mainly of mucocutaneous manifestations, i.e., skin rashes, stomatitis, diarrhea, conjunctivitis and corneal ulcerations. Evidence of antitumor potential in far-advanced disease and lack of myelosuppression point to the need for additional trials of PALA in a more favorable selection of patients with breast cancer. © 1982.