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High prolactin levels are associated with more delirium in septic patients

par Nguyen, Nam ;Huyghens, Luc;Schiettecatte, Johan;Smitz, Johan;Vincent, Jean Louis
Référence Journal of critical care, 33, page (56-61)
Publication Publié, 2016-06

Article révisé par les pairs

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Résumé :

Purposes: We investigated whether high prolactin levels were associated with delirium in septic patients because neuropsychiatric disorders are frequently associated with hyperprolactinemia. Materials and methods: Prolactin levels were measured daily for 4 days in 101 patients with sepsis. Delirium was assessed using the Richmond Agitation Sedation Scale and the Confusion Assessment Method in the ICU. Results: Delirium developed in 79 patients (78%) and was more common in patients older than 65 years. Prolactin levels were higher in patients with delirium than in those without over the 4 days of observation (P = .032). In patients with delirium, higher prolactin levels were associated with a lower incidence of nosocomial infection (P = .006). Multivariable logistic regression showed that the Sequential Organ Failure Assessment score at intensive care unit admission (odds ratio, 1.24; 95% confidence interval, 1.04-1.48; P = .002) and the combined effect of prolactin levels with age (odds ratio, 1.018; 95% confidence interval, 1.01-1.031; P = .006) were associated with the development of delirium. Conclusions: High prolactin levels may be a risk factor for delirium in septic patients.