par Cedergren, Robert;Sankoff, David;Larue, Bernard;Grosjean, Henri ;Söil, Dieter
Référence Critical reviews in biochemistry and molecular biology, 11, 1, page (35-104)
Publication Publié, 1981
Article révisé par les pairs
Résumé : The study of tRNA molecular evolution is crucial to understanding the origin and establishment of the genetic code as well as the differentiation and refinement of the machinery of protein synthesis in prokaryotes, eukaryotes, organelles, and phage systems. The small size of the molecule and its critical involvement in a multiplicity of roles distinguish its study from classical protein molecular evolution with respect to goals and methods. Here, theauthors assessavailable and missingdata, existingand needed methodology, and the impact of tRNA studies on current theories both of genetic code evolution and of the evolution of species. They analyze mutational "hot spots" the role of base modification, synthetase recognition, codon-anticodon interactions and the status of organelle tRNA. © 1981 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.