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No Evidence for the Benefit of Gonadotropin-Releasing Hormone Agonist in Preserving Ovarian Function and Fertility in Lymphoma Survivors Treated With Chemotherapy: Final Long-Term Report of a Prospective Randomized Trial.

par Demeestere, Isabelle ;Brice, Pauline;Peccatori, Fedro Alessandro;Kentos, Alain ;Dupuis, Jehan;Zachée, Pierre;Casasnovas, Olivier;Van Den Neste, Eric;Dechene, Julie ;De Maertelaer, Viviane ;Bron, Dominique ;Englert, Yvon
Référence Journal of clinical oncology, 34, 22, page (2568-74), Selected for editorial
Publication Publié, 2016-05

Article révisé par les pairs

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Résumé :

We have reported previously that after 1-year follow up, gonadotropin-releasing hormone agonist (GnRHa) did not prevent chemotherapy-induced premature ovarian failure (POF) in patients with lymphoma, but may provide protection of the ovarian reserve. Here, we report the final analysis of the cohort after 5 years of follow up.