par Rao, C.N.;Velidi Hanumantha, Rao 
;Verbruggen, Leon A;Orloff, Serge
Référence Scandinavian journal of rheumatology, 9, 4, page (280-284)
Publication Publié, 1980
;Verbruggen, Leon A;Orloff, Serge Référence Scandinavian journal of rheumatology, 9, 4, page (280-284)
Publication Publié, 1980
Article révisé par les pairs
| Résumé : | In rats with adjuvant-induced arthritis, the effect of (+catechin (CA) and 0-(βhydroxyethyl) rutosides (HR) on the activity of certain lysosomal acid hydrolases, viz., βglucuronidase, βN-acelyl glucosaminidase and cathepsin D in serum, liver, kidney and spleen and the stability of liver lysosomes was studied. The activity of these enzymes in arthritic tissues and serum increased significantly. The total activity of βglucuronidase in the lysosome-rich fraction from arthritic liver was appreciably decreased, while its release was significantly increased. These results demonstrate the fragility of lysosomes in arthritic tissues. Administration of CA or HR to the arthritic animals was found to have a prophylactic action by stabilizing liver lysosomes and reducing the free lysosomal enzyme activities in serum, liver, kidney and spleen. CA was more effective than HR. © 1980 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
