par Cavalli, Franco;Rozencweig, Marcel 
;Renard, Josette;Goldhirsch, Aron;Hansen, Heine
Référence European journal of cancer, 17, 10, page (1079-1082)
Publication Publié, 1981
;Renard, Josette;Goldhirsch, Aron;Hansen, HeineRéférence European journal of cancer, 17, 10, page (1079-1082)
Publication Publié, 1981
Article révisé par les pairs
| Résumé : | In a disease-oriented phase II study, 26 patients with hepatocellular carcinoma were treated with oral VP-16-213 at 120 mg/m2/day for 5 consecutive days, repeated every 3 weeks. Of 24 evaluable patients, 3 achieved partial remission (PR) for 12, 16 and 35 weeks respectively. Minor regression or stabilization of the disease (NC) was achieved in 8 patients for a median duration of 15 weeks. Patients with PR and NC experienced similar median survival (22 weeks), whereas non-responders had a median survival of less than 8 weeks. Results of this trial indicate that VP-16-213 has limited but definite anti-tumor activity in hepatocellular carcinoma. © 1981. |
