par Nitelet, Antoine ;Evano, Gwilherm
Référence Organic letters, 18, page (1904-1907)
Publication Publié, 2016
Article révisé par les pairs
Résumé : An efficient and general system for the halogen exchange reaction in alkenyl halides has been developed. Upon reaction with catalytic amounts of copper iodide and trans-N,N’-dimethylcyclohexane-1,2-diamine in the presence of tetrame-thylammonium chloride or bromide, a wide range of easily accessible alkenyl iodides can be smoothly transformed to their far less available chlorinated and brominated derivatives in excellent yields and with full retention of the double bond ge-ometry. This reaction also enables the chlorination of bromoalkenes and could be extended to the use of gem-dibromoalkenes.