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Identifying reaction modules in metabolic pathways: bioinformatic deduction and experimental validation of a new putative route in purine catabolism.

par Barba, Matthieu;Dutoit, Raphaël;Legrain, Christiane ;Labedan, Bernard
Référence B M C Systems Biology, 7, page (99)
Publication Publié, 2013

Article révisé par les pairs

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Résumé :

Enzymes belonging to mechanistically diverse superfamilies often display similar catalytic mechanisms. We previously observed such an association in the case of the cyclic amidohydrolase superfamily whose members play a role in related steps of purine and pyrimidine metabolic pathways. To establish a possible link between enzyme homology and chemical similarity, we investigated further the neighbouring steps in the respective pathways.