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Gene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible mice versus cerebral malaria-resistant mice

par Delahaye, Nicolas NF;Coltel, Nicolas ;Puthier, Denis;Barbier, Mathieu;Benech, Philippe;Joly, Florence;Iraqi, Fuad FA;Grau, Georges E.;Nguyen, Catherine;Rihet, Pascal
Référence BMC genomics, 8, page (452)
Publication Publié, 2007-12

Article révisé par les pairs

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Résumé :

Microarray analyses allow the identification and assessment of molecular signatures in whole tissues undergoing pathological processes. To better understand cerebral malaria pathogenesis, we investigated intra-cerebral gene-expression profiles in well-defined genetically cerebral malaria-resistant (CM-R) and CM-susceptible (CM-S) mice, upon infection by Plasmodium berghei ANKA (PbA). We investigated mouse transcriptional responses at early and late stages of infection by use of cDNA microarrays.